Originally Posted by jayeff

This is going to be like those vodka threads in which we get to see who cares more about looking cool than what the stuff actually tastes like. At least for anyone building sites or pages, the only sensible answer has to be the screen resolution which is currently the most popular with surfers.

Sure you can check designs at lower resolutions afterwards, but unless something is totally borked, how many are going to go back and make minor changes?