Most metal guys these days are using Mesa/Boogie. They're pretty great. You can go for a head and cabinet arrangement or a rack (my preference) if you want to be a little more portable and modular. In general you're definitely going to want a balls-loud tube amp--there is no real substitute.
Check out the Triaxis and a 50/50 if you have a few bucks.
The Formula and the 20/20 is pretty nice too and can be had on e-bay for around 750.
If you aren't playing shows and just want to fuck around, there's lots of good, cheap options. The POD has some good sounds and tube emulation.
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