yes, I have done some. There is some pretty major changes "under the hood" in the data base area, such that many plugins that directly access the databased to fill in information get broken. You should take your current list of plugins and look to see if there are replacements.
This is also an upgrade you can't go back from easily, so make sure you back up your databases before you upgrade, in case you don't like the results. This is a less urgent upgrade, as this isn't a security patch but an actual code upgrade.
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