I just bought a new comp a couple weeks ago with vista and have had no problems. It's definitely a lot more sluggish than XP but apparently SP1 (out in Jan 08?) is supposed to speed things up a bit.
If you're not needing to play DX10 games then XP is probably a better choice but if you're getting a new computer then by all means go nuts, just make sure you got oodles of RAM.
[Disclaimer: I'm not responsible for anything if downgrading to Vista turns tragic.]
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