Don't know about #1 but 2 pass anything should yield better compression than 1 pass..
2. Every 45 frames will be better than every 300.. A key frame is basically an uncompressed frame.. every "frame" after that is compressed as the difference between that keyframe and the current frame. So the more keyframes the better the quality of the video but also the larger the file. I'd assume that 1:1 means that the frame rate of the output is the same as the input file. Again, reducing the frame rate will reduce the file size while still looking good.. Most people can't tell the difference between 30fps and 60fps or even 15fps.
You maintain the aspect ratio...
Yeah, the VP6 compressor is better quality than the older one in ffmpeg... Surfers need to be using a more recent version of Flash in order to watch them though but I'm sure most have upgraded to at least v8.. Not sure if there's licensing issues though with VP6...
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