Did you switch providers recently? Or did your ISP recently update their network's mail configuration rules?
The message you are getting usually occurs when an ISP doesn't allow you to connect to an external SMTP server on port 25 and thereby locks you into using their SMTP server exclusively. They do this to block spammers. Perhaps that could be the issue. Could be.
External mail providers have circumvented this by providing alternate ports (587, 2525, et al)
First, try using your ISP's SMTP server as outgoing for all of your accounts. If everything works then you know that it's their new anti-spam policy.
That way can end up being a pain if your ISP's SMTP server sucks (or if you travel with a laptop) though, so a permanent fix is to use the alternate port configuration from your external mail account providers.
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