Been there a whole lot of times! Happy to advise...
I would say Animal Kingdom is a must, I think we had the most fun there with the kids. Depending on their ages, Epcot can be great or not.... In my opinion, Epcot is somewhat lost on kids under 7 due to attention span.
At disney my advice is pretty simple... everyone needs to wear really comfortable shoes and outfits. We all laugh about fanny packs but I'd recommend this over your wife bringing a purse any day. The parade and fireworks at night is awesome but also an absolute cluster fuck of a rude crowd with pushing. You basically have to get there early to get a decent position but by the time its 'on' expect that you have people pushing in - so the best bet is to get a spot right on the street but to do so I bet you need to be 45 minutes early. We ended up putting the kids on our shoulders and I'll tell ya that was the hardest half hour ever after a long day.
If you have a daughter there are opportunities at every park to purchase a princess lunch or tea party....... I did one with Elizabeth at Epcot and it rocked.
My advice would be to get a general idea of what everyone wants to see when you start each day. I found that we have had the most fun when there is no stress... let the kids be kids and take a break or even go back to the hotel for a nap mid-day. Bottled water on a strap makes it easy to stay hydrated and depending on the time of year those misting fans are pretty good.
Brad