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1-if she hit you first with a weapon
2-if she is about to hit you with a weapon
3-if she is directly endangering the life of you or your loved ones.
4-if you are the hero in an action movie and the only way to survive is for her to be quiet, but she just won't, so you hit her on the head with something and she goes unconscious. wakes up later, pissed, but without a scratch.
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