Originally Posted by WarChild

I'm fairly certain that liver damage can still happen with intramuscular injections. Remember, the Liver holds up to about 13% of all the blood in the body at one time. One of it's purposes is to clean drugs and what not out of the system. Intramuscular drugs still end up in the blood stream, and thus by definition in the liver.

The danger, as far as I understand it, with oral steroids is the the liver has to process the drug twice where as only one time with IM.