Just a reminder to keep these sites in mind:
http://www.therainforestsite.com
http://www.thehungersite.com
http://www.theanimalrescuesite.com
http://www.thechildhealthsite.com
http://www.theliteracysite.com
http://www.thebreastcancersite.com
They have stores with lots of giftable type items, some pretty cool housewares, cocoa mixes, ornaments, etc etc, and for every purchase some of the proceeds go to the site's relative cause. They also have a "gifts that give more" section where you can donate towards things like "spay or neuter an Indian street dog" or "buy books for a poor schoolchild" as gifts or just because.
I know we've got the Webmaster Toy Run, but I thought it would be nice if we had a thread where we talked about other ways to give to those in need, both during the Holidays and year round.
If any of you have any other links similar to the sites I posted, please do reply and let me know!