Chameleon is a big help if you drop a decent amount of money on submit passes, spend time applying for free passes, test what niches and sites convert TGP traffic well, submit multiple galleries every day, etc.
Unfortunately your questions really cannot be answered because there are too many factors involved. Submitter A might get 4x the traffic Submitter B gets but how much is each investing in submit passes? What niches are being promoted? If niche A converts at 1:1200 and niche B converts at 1:3000 there will be a huge difference in sales over the course of a month. Generally speaking the software won't get you blacklisted but if you make mistakes using it you will.
Take a look at their
blog for lots of useful info. I'd also budget in some passes at
SubmitPasses.