I've done it with 2 chihuahuas, we called all potential places we wanted to stop at ahead of time to make sure they accepted pets. The biggest problems we faced was to find a quiet place for the dogs to do their needs. Also, many hotels charge an extra $250+ deposit when you rent a room, so if you're staying 7 nights, you end up with a couple of $k on hold on your credit card. Beside that it was pretty easy, but the 2 dogs barely weigh 20lbs total...
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