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Good luck Majestic!
I used for a long time a combination of this two software bundles to manage email lists from 5k-50k. Further I would recommend not to use a Webdatabase or equal solution.
What works pretty fine was Easy Email Verifier and Easy List Manager.
easysoftmade.com
For sending mails to different groups of users with automated opt-in/out verification, TIME SHEDULED SENDING, blacklist and reports go for Atomic Mail Sender (AMS). It's a perfect choice and the mail adresses can be easily imported from any file or database.
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