I'll speak up for some of my favorite restaurants in SF:
Sebo or Domo for sushi, Absinthe, Suppenkuche, Chez Papa (go to the Resto not the Bistro), Katana-Ya (great ramen and open late night), Catch and Woodhouse Fish Co. in the Castro are both good for seafood.
I'll also second Ike's. I once stood in the rain to get a sandwich there.
Clubs/Bars:
Press Club and Amelie (both really good wine bars), Harlot, Mr. Smith's, Art Bar
If you're ever unsure, check out
Yelp. It's a SF staple, but take the comments with a grain of salt.