I am in Littleton, which is a suburb on the south side of Denver.
The entire metro area from Boulder down to Littleton is a bit more "outdoorsie" than many other places I've been, lived, traveled. What I mean is that the area -- and many, many of the people -- are more about outdoor fun. Hiking the mountains, skiing / snowboarding, mountain biking, and things along those lines. Golf is huge in spring and summer -- lots of beautiful courses all along the front range. In Colorado I don't meet many "gamers" or others that stick more to inside activities. Boulder in particular is a very "Healthy" area -- with healthy activities and health food stores and along those lines.
Conversely, I also have a place in Clearwater, Florida. Its more rare to find people (meaning in the range of 18-26) that are into outdoor activities that call for using muscles -- like the bikes and hiking -- in my part of Florida. I'm 50 and people that work for me think I am weird as fuck for riding my bike just 6 miles daily, but back in Colorado I get passed on the bike trails by people older than me and I have a guy working in the office that bikes 16 miles to work and 16 back 4 days a week this time of year. The main outdoor activity I find in that part of Florida is fishing -- which is killer popular, but not as athletic as hiking / skiing / boarding / biking.
Colorado -- darn health food stores and medical marijuna stores all over. Tampa bay area, only one health food store within miles of me and no medical marijuna yet.
As for business, I have found two major differences...
In Colorado we have more tech related stores -- like Computers and such. If I want a new fancy video card TODAY, I don't have to order online. I can hit Micro Center or a few other such places and get it 7 days a week. No so in Clearwater / ST Pete / Tampa area.
Next would be photo and video related. Photography and pro video production is real popular in Colorado. If I want some sort of new pro-level lighting or camera or other studio gear, I can just go buy it at any of 4-5 places in the metro-Denver area. But, in the metro-Tampa Bay area, not so... not one store "stocking" the latest and great from Canon or Nikon, etc.
For pro-level production, Denver has it all -- from great rental places (
http://www.lsidenver.com/studiocomplex.html ,
http://camren.com/facility/studioc.html and more) and pro-level camera stores (
http://www.denverprophoto.com/products.html ,
http://www.englewoodcamera.com/products.html , and more).
If you are into healthy, scenic, and outdoorsie stuff -- Boulder, right at the foot of the rockies is a winner.