You may want to disable any plugins not in use, there are many resource intensive plugins that can cause server issues (due to the fact that they were written poorly). Memory is key when it comes to wordpress, load it up as best you can and be sure your web server and mysql configurations are set to be as light weight as possible. A good caching plugin will go along way as well, we like w3-total-cache. It allows you to use many existing caching methods transparently and works with CDN networks (like ours ;) which will help offload static traffic/requests of your machine.
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