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This is what I do - 45 minutes work (I use an alarm clock gadget) and 15 mintues break; then AT LEAST 1 hour walk (more like 1.5 hours) every day (I stopped going to the gym).
And when I feel any discomfort in my hands, I start doing something that doesn't require me to use the mouse or type - like watching online tutorials, etc.
As for standing up while working, that's simply not possible, not to say that it probably comes with its own set of problems.
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