Akismet, good rules like "must have at least one approved comment "and then manually reviewing new comments regularly. Also, if the commenters link looks like shit, I reject the comment no matter how good it is.
I've disabled commenting on all of my adult sites. I have yet to see a comment that was really worth a shit on an adult site. All of my comments were something like "so hot", "moar please", "bitch is ugly", "why you post so much dick, fagget". Mainstream is marginally better.
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