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Best way to boost performance on most Lamp based apps is by lessening the load on the db and web server....
Do this by caching as much as possible.
Cache front end ie forward proxy such as Varnish or Nginx, php opcode caching..ie apc, application caching.ie w3cache or similar, object caching.. ie memcached, using query caching on the database... etc etc.
I've been researching and benchmarking different setups lately (mostly with wordpress and drupal) and it's amazing how much of a difference it makes. I've seen #/reqs per second increase 20x with the right tweaking....
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I don't endorse a god damn thing...... 
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