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I think it can work. I never quite bought the idea of Sheen as a babe magnet; of course, Kutcher as a genius dotcom billionaire is also a bit of a stretch. But, Pam Greer is priceless. (Can't miss "Archer" !!!) And as for changing key cast members late in the show's lifespan, it worked out pretty well for M*A*S*H.
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