A couple of points:
-If you really had 2million or 2billion e-mails in a list you would be the biggest email marketing guru of all time and you would not need advice on what to do with it.
-Sending out 2 million or 2billion e-mails is mass bulk unsolicited spamming, exactly what spam filters hate and look for, end of story. Your IPs, domains, mail servers, name servers and/even your entire IP range will get blacklisted everywhere.
-Just the hard bounce rate from 2million (let alone 2 billion) e-mails is enough to burn through what ever IP reputation you may have in a single day.
-If you actually were stupid enough to purchase this list then: AHAHHAHAHAHAHAHAHAAA! I'm sure its pristine and un-used and all the people on it are just dying to get their 1000th unsolicited offer of the day.
My advice is that you throw away the list and make your own...
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