Not really sure about "affecting" me but will mention Punch-Drunk Love and Eternal Sunshine since in both I could relate to the main characters a lot.
That said, just thinking of movies that really stand out as affecting me, I'd have to go with something horror. I have to admit, not that I fly often but I certainly wasn't eager to for a while after Final Destination. Also, seeing The Omen as a kid freaked me out quite a bit and gave me nightmares.
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