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You could easily create something that utilizes a web service and have it for browser and even desktop although might be a pain in the ass with the extra work of building the desktop app, but it would be easy to integrate the data also to mobile.
You have mentioned api's in the past which are essentially web services and you can easily integrate that into desktop or mobile apps (not that you would want to but just an example)
I think what DWB said is a good idea and you could architect in such a way where it can be online based but also can fit into desktop or mobile applications.
If you set up a proper web service data is more easily accessible where you can do whatever you want with it
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