Yes it is possible. I do it on all of my sites. I actually use a combination of three ad programs:
Plugrush,
Juicy Ads (this one is set as an alternate url to
Plugrush), and
Sex Goes Mobile (this one is set as an alternate url to
Juicy Ads).
Most of the traffic gets sold at
Plugrush, about 10-20% goes through
Juicy Ads, and the remaining traffic gets redirected to
Sex Goes Mobile. I have not been using the last one for a long time, but it is a rev share, and I already generated some sales.