I use Adrotate and OpenX.
Like femdomdestiny said, OpenX is a pain in the ass to set up and personally,I think it's a pain in the ass to maintain as well. But, it has some features that can be useful if you want your advertisers to be able to create and manage their own campaigns.
Adrotate is simple, straight forward, and I prefer it for WP sites. I have not upgraded to the stripped down version nor paid for the new one.
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