While I pick up what you're putting down, I really haven't had any issues.
I run an iMac at the office, and carry my MacBook Pro between the office and home. I use a program called Teleport that allows me to just open my MacBook Pro up next to my iMac on a stand and use my iMac's keyboard and mouse on it as if it was just another display.
I am however upgrading my hardware here in a couple months and will get rid of the iMac in exchange for a beefed up MacBook Pro and 2 daisy chained Thunderbolt displays both at the office and at home where I'll just dock my MacBook Pro between the two setups.
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