If you have a good product and know how to market it, you'll be fine and you can use channels like Amazon/eBay/Etsy etc. in addition to your own shop to promote & sell your products.
Use a service like shipstation to consolidate all orders into a single place for easy processing and shipping. Returns are rare as long as you're not misleading anyone with your product descriptions and aren't selling junk. Women will likely spend more than men and they don't really bitch at all... as a matter of fact, they're very understanding and easy going as long as your support is top notch.
But remember, just because you build it doesn't mean they'll come. You need to understand your demographic, how to reach them, how to get them to spend, and how to get them to come back and spend more.
Good luck!
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