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There really isn't a one-size fits all answer. It depends on your traffic, pre-sales, pre-screening, demographics, etc. If you analyze your own stats per program, right down to your cost/click or cost/sale to a program over specific periods of time, then study your net revenue at $/click or $/sale. At that point, you can tell which is better for you for that specific program.
Without data for your OWN traffic/demographics/promotional methods, you're left with guesswork.
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NSFW
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