Also looking here at a setup
https://www.pugetsystems.com/workstation.php
If you want to get REALLY serious they offer Xeon processors.
I configured one with a XEON 12 core processor...but they have even more powerful ones than that.
I also configured it with a Quadro M5000 card.
By the time I got done playing around with the configuration, the cost is over $7000
I haven't pulled the trigger on it yet. Just looking at the moment.