I've worked with SalesForce, Pipeline Deals, SugarCRM and ZOHO CRM.
It really depends on on what capabilities you want to have.
SalesForce is an enterprise level solution that is managed and super powerful at a lot of different things. Maybe too many things.... Pipeline looks nice and collaborates well but I have found it a little too arduous to track some of the basic sales tasks. Zoho CRM had the best value and was simple to setup and use but it cost money ;) Sugar rocks if you want free (which is why it wins for me) or if you want to do custom hooks with your other systems because it's open source.
At the end of the day, it's whatever is going to satisfy your sales management goals as they all can assist in organizing sales people.
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