Being a tall guy I usually have problems with chairs (their maximum height is often too low) and screen angles (they don't tilt upwards enough with the default stand). I use a notebook occasionally, but I can't imagine spending hours every day angling my head down to see it. There's also the pissy little keyboards to contend with.
If you're into minimalism, and not a tall freak, then I guess a laptop is ideal, otherwise, I don't see why you'd sacrifice the ergonomic benefits of a proper desktop setup, with a full sized keyboard, and a screen that is raised more than an inch above the desk...
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