Originally Posted by BigFurry

1. In the past you needed to create your own account at each ad network. You link them in your AdSpyGlass admin.
This is what I use. AdSpyGlass optimizes the ad serving and shows the most profitable ads. You get paid by the ad networks, AdSpyGlass is just an optimization javascript in this case. You pay for the optimization service (or let them skim 10%).

2. It seems like there is a new option now, you can choose to get paid by AdSpyGlass. As I understand in this case AdSpyGlass uses its own ad network accounts, and you get paid by AdSpyGlass.
I'm sure AdSpyGlass takes its cut, and you'd earn more by signing up all 35 ad networks... But if you only added 3-4 ad networks, you might earn more getting paid by AdSpyGlass since they use a big number of networks?
I haven't tried this option yet, but I should.

This is from their FAQ: