Tbh, it's not really a question you need to ask, cos the answers are so easy for you to find out ... and any answer anybody gives you is a guess at best. Your traffic is your traffic not theirs. You will, or should, know your own traffic better than anyone else here.
Sign up to some more cam sponsors - or any other product you want to try - place their creatives in exactly the same spot (if it's a simple banner, run a banner rotation script on autopilot) and monitor the EPC. Then you can pick your best performers and try to see if the EPC improves with different creatives. You can also see if different products/creatives work better with different devices/countries etc.
You might get a lot of other answers. But they are still really just guesses.
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