Basically what I'd say is if you use the server for TGP galleries, then go for it (KeepAlive On), if you serve mainly seperate files, turn it off.
Let's take an example with a gallery of 20 thumbs. With KeepAlive Off, the browser will open 1 connection for the HTML, will parse it then will open 1 connection to get each thumbs (which totals 21 connections). On the other hand, with KeepAlive On, the browser will open 1 connection for the HTML, parse it and reuse the connection to get the thumbs. Thus in a perfect world it would use only 1 connection instead of 21. In reality it doesn't work exactly like that, because usually browsers will open 2 connections at the same time to speed up things. But it still saves you a lot of connections and thus processing time and server ressources.
But if you serve for instance .exe files or something like that, chances are thin a browser could reuse the connection and thus is pointeless. Just be sure to follow thepiper's advices and you'll be alright!
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