Guys, take it from me, my doctor told me there is 1 sure fire cure for this:
Support your arm.
Sit so the weight it resting 2 inches past your elbow or so on the desk, then get one of those gel wrist-rests and put it under your wrist. balance the weight between the two and use your wrist slightly / but mostly your fingers to move the mouse.
I had EXTREME pain for a week a few years ago and my doctor immediately ordered me to take time off work or risk permanent damage. I rested up and followed his instructions for mouse operation safety ( haha yes that's what he called it ) and now my wrist VERY rarely hurts. Only when I am using a laptop on a couch or something for a few hours does CTS flare up, and then only slightly.
Watch out people, I have known a few people to basically have to retire from much computer use as their right hand had lost a lot of mobility.
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