There are a bunch of people on this board who will confirm that I know nothing about Vegas ;)
...but....
I thought I would throw in my two cents.....
Chris is right about the Palm having the coolest clubs.....the hottest club in Vegas right now, hands down, is RAIN inside the Palm.....but as for the best place to STAY and PARTY is absolutely the Hard Rock. If you want to pick up girls that are NOT pros and you can't at the Hard Rock pool....then you better make your way to the Chicken Ranch.
Since you are going....here is SweetT's List of Hot Spots in Vegas:
Monday Night: Foundation Room - Mandalay Bay (if you are not a member, tell them that you want to talk to someone about becoming a member and they will give you a one day pass.....you may actually like it enough to join
Tuesday Night: Studio 54 - MGM Grand
Wednesday Night: Ra - The Luxor
Thursday Night: Latin Night Club Rio - The Rio -OR- HipHop Night Ra - The Luxor
Friday Night: Rum Jungle - Mandalay Bay -OR- Skin - The Palms
After Hours: Jaguars (yes, a strip club is doing a REAL after hours)
Saturday Night: Rain - The Palm
After Hours: Venus - The Venetian
((((before you say anything, I left off Drai's on purpose...nobody goes there anymore

)))))
Sunday Night: Light - Belagio After Hours: SRO
Hope you guys have fun!!!
--T