Using antibiotics increases allergies - GoFuckYourself.com

aka123 · 08-26-2014, 03:26 AM

"The prevalence of food allergy is rising at an alarming rate; the US Centers for Disease Control and Prevention documented an 18% increase among children in the United States between 1997 and 2007. Twenty-first century environmental interventions are implicated by this dramatic generational increase. In this report we examine how alterations in the trillions of commensal bacteria that normally populate the gastrointestinal tract influence allergic responses to food. We identify a bacterial community that protects against sensitization and describe the mechanism by which these bacteria regulate epithelial permeability to food allergens. Our data support the development of novel adjunctive probiotic therapies to potentiate the induction of tolerance to dietary allergens.

Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota. "

http://www.pnas.org/content/early/20...4-d11b55761821

Maybe munching those antibiotics like candy is not that good idea? Not to mention to developing resistant bacterias.

The conclusions includes also shitty microbiota populations because of bad diet, lack of breast feeding, etc.

klinton · 08-26-2014, 04:25 AM

its obvious thing sadly....

Major (Tom) · 08-26-2014, 08:05 AM

this has been common knowledge for at least 15 years. no?
ds

aka123 · 08-26-2014, 08:14 AM

Quote:

Originally Posted by DukeSkywalker

this has been common knowledge for at least 15 years. no?
ds

No.

Liberal usage of antibiotics has been known to be bad, but the link to allergies is new information, not to speak of the general conclusions about your ingestion channel (environment) and allergies.

_Richard_ · 08-26-2014, 08:22 AM

Quote:

Originally Posted by DukeSkywalker

this has been common knowledge for at least 15 years. no?
ds

never heard of it

Barry-xlovecam · 08-26-2014, 08:30 AM

Well, if you really need antibiotics use them.

Like any medication there is real need also there is misuse and abuse.

Major (Tom) · 08-26-2014, 08:50 AM

Quote:

Originally Posted by aka123

No.

Liberal usage of antibiotics has been known to be bad, but the link to allergies is new information, not to speak of the general conclusions about your ingestion channel (environment) and allergies.

well i knew for about 15 years. it's definitely been published before.
ds

08-26-2014, 03:26 AM	#1
aka123 Confirmed User Industry Role: Join Date: Jul 2014 Location: 64 00 N, 26 00 E Posts: 4,450	Using antibiotics increases allergies "The prevalence of food allergy is rising at an alarming rate; the US Centers for Disease Control and Prevention documented an 18% increase among children in the United States between 1997 and 2007. Twenty-first century environmental interventions are implicated by this dramatic generational increase. In this report we examine how alterations in the trillions of commensal bacteria that normally populate the gastrointestinal tract influence allergic responses to food. We identify a bacterial community that protects against sensitization and describe the mechanism by which these bacteria regulate epithelial permeability to food allergens. Our data support the development of novel adjunctive probiotic therapies to potentiate the induction of tolerance to dietary allergens. Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota. " http://www.pnas.org/content/early/20...4-d11b55761821 Maybe munching those antibiotics like candy is not that good idea? Not to mention to developing resistant bacterias. The conclusions includes also shitty microbiota populations because of bad diet, lack of breast feeding, etc. Last edited by aka123; 08-26-2014 at 03:34 AM..

08-26-2014, 08:30 AM	#6
Barry-xlovecam It's 42 Industry Role: Join Date: Jun 2010 Location: Global Posts: 18,083	Well, if you really need antibiotics use them. Like any medication there is real need also there is misuse and abuse.

08-26-2014, 04:25 AM	#2
klinton So Fucking Banned Industry Role: Join Date: Apr 2003 Location: online Posts: 8,766	its obvious thing sadly....

08-26-2014, 08:05 AM	#3
Major (Tom) Anti Communist Industry Role: Join Date: Nov 2003 Location: Null Posts: 29,752	this has been common knowledge for at least 15 years. no? ds