HairyChick

Would you do it? I’d rather not as it’s easier to take a pill a day instead of surgery that restructures your body

This Pill Could Reverse Type 2 Diabetes

Most people don’t think of type 2 diabetes as a disease you can cure. Well, for some patients, it’s possible we can — with gastric bypass surgery. It can also lead to potentially life-saving weight loss, lower blood pressure, and relieve depression. In fact, in one study of 20,000 patients who had gastric bypass surgery, 84 percent found their type 2 diabetes completely cured.

There are downsides, however. Possible side effects include hernias, infection, blood clots, ulcers, and even death.

So, what if type 2 diabetes patients could get the same benefits of gastric bypass surgery without going under the knife?

Researchers from Brigham and Women’s Hospital (BWH) think they’re on track to figure out just how to do that. They published their findings Monday in Nature Materials.

A quick primer on gastric bypass surgery. Though the specifics can vary, the surgery basically “shrinks” the size of a person’s stomach by blocking off a large portion of the organ from the rest. Surgeons do the same in the small intestine.

With a stomach that can now only hold a very small amount of food, patients can no longer eat large meals. Additionally, because the food they do eat no longer travels through the entire small intestine, the body doesn’t absorb as many nutrients. Cumulative effect: weight loss.

People with type 2 diabetes have unusually high blood glucose (sugar) levels. Food consumption plays a major role in this elevation, and weight loss is one way to effectively treat it. So, people get gastric bypass surgery, lose weight, and reverse their diabetes. Cut and dry, right?

Not according to doctors. Many aren’t convinced that weight loss deserves all the credit for reversing type 2 diabetes in gastric bypass patients. In fact, they don’t really know why the surgery helps, just that it does.

The BWH team’s gastric bypass alternative could help, too. Here’s how it works.
Using an FDA-approved drug called sucralfate as a base, the team engineered a compound they call LuCI (Luminal Coating of the Intestine). Once ingested, the compound temporarily coats the inner lining of the intestine. This essentially replicates how the surgery makes part of the intestine unable to absorb nutrients. And it seems effective — within an hour of administration, LuCI lowered rats’ after-meal response to glucose by 47 percent.

“What we’ve developed here is essentially, ‘surgery in a pill,'” study co-lead author Yuhan Lee said in a press release. “We’ve used a bioengineering approach to formulate a pill that has good adhesion properties and can attach nicely to the gut in a preclinical model. And after a couple of hours, its effects dissipate.”

The pill, of course, isn’t quite ready to go on sale yet. Next, the researchers plan to test LuCI in diabetic and obese rats. If it works as hoped, the drug could one day provide a much-needed replacement for gastric bypass surgery in reversing type 2 diabetes.

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GFED

My dog helped me with my type 2 diabetes. My blood sugar used to be in the 250+ range. He saved my life in many ways. Usually around 100-150 now. Although sometimes it gets too low now. I've had it under 50 a couple times and started feeling feint.

Get a dog.
Walk your dog.
Play with your dog.
Love your dog.

FUCK YOUR PILLS

GFED

Hiking with my best friend. https://imgur.com/gallery/7josn9t

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brassmonkey

drop the lard no need for a pill. oh exercise. i don't mean lifting food

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HairyChick

Mine is fine, usually blood sugar is 75. I eat sugar daily but little amounts. Losing weight fixed me.

I tried no sugar years ago and my blood sugar rose. Makes no sense, right? The body needs sugar and by denying it, my own body made it but made too much. I began eating a little every day, just a few Hershey’s Kisses or an extra serving of carbs ( turns to sugar) and it’s been under control. I’m still careful and my A1C is 4.6. Used to run around 6.8 or so.

Gastric bypass surgery is serious

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brassmonkey

jeezus that's when you eat out of control your stomach is like only large enough to fit like 3 peanuts right?

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oppoten

You k*kes are getting high on your own supply.

The whole point of this crap is 'fewer white babies'. If it's an anti-fertility message, you need to keep quiet about it

HairyChick

Yep. Any more and you throw up. They reroute the intestines, too, so your body absorbs less nutrients. You eat less and lose weight, but eating better food that's not fatty and salty is more important IMHO.

On "My 600 lb. Life" the statistics show only 5% of gastric bypass patients on the show are successful in the long term

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Bladewire

You were 600 pounds? How long for you to lose all that weight?

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pimpmaster9000

it is a shame when the USA invents some medicine like the hepatitis pill that costs 1000$/pill and you need 80.000$ for a cycle...what ever they make costs 1000$/pill...it is not about curing it is about medicinal blackmail...

I hope that the cure for cancer is not found by the USA...so that it remains accessible to everybody and not just the 1% of the population of the USA...

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GFED

USA is a business. It's a shit eating corporate entity.

I hate corporate fucktards as much as political fucktards. What are we suppose to do?

Until we quit fighting each other and revolt against our government instead we will always be slaves. It will never happen.

There are too many happy slaves drinking their Starbucks coffee and watching their shit Netflix crap to give a fuck. Consumerism is a disease.

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TheSquealer

Not eating like an asshole reverses type 2 diabetes. Seriously, what the fuck is wrong with you people?

Stop eating sugars and grains and there is no type 2 diabetes.

This is very basic nutrition 101 stuff.

Jesus... "a pill...".

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Rochard

TheSquealer

No protein... you die.
No fats.... you die
No carbohydrates..... you lose weight, blood lipid profiles stabilizes, energy levels go up, cholesterol levels are healthy, you require far less sleep, you have improved mental acuity etc etc etc.


But yeah... "less fats"

It's the "less fats" part that is the genesis of the obesity epidemic to begin with. In fact, the policies and that recommendation was based solely on the fraudulent studies of one scientist - Ansel Keys. Furthermore, the subsequent dietary guidelines for the government were they drafted by a vegan labor reporter for a small Rhode Island newspaper.

Besides the stupidity of "less fat", you'd have to be one of the most useless and lazy people on the planet to be morbidly obese, immobilized and shoveling 5-15,0000 calories down your throat each day (i..e. someone is also helping you do this) and then decide 'i need to risk my life with surgery" instead of not eating 14 bags of cookies each day and dropping 10-20 lbs a week... and the doctors who perform these surgeries are criminals in my opinion. There is no medical solution to eating ice cream and cake all day.

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Rochard

dyna mo

op, read a book or 3 on nutrition, your info is outdated.


type 2 diabetes is a lifestyle choice

fat is not your enemy.


etc.

GFED

I'm unable to process the carbs. Such as potatoes, rice, and noodles. Those have been a main staple for many years. Is that not an effect from the diabetes?

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dyna mo

My understanding is that every diabetic's situation is unique. I'm not sure why you have a carb intolerance. How do you know you don't process those?

GFED

Just a guess since I never intaked a lot of sugar and still had really high levels. My mother was the type that would only let me eat Chinese desserts because Americans use too much sugar. I actually prefer a Chinese cake over an American one. She once bought a package of Oreos from the market and ended up scraping the filling out of each one and put them back in the package.

After changing my diet and walking 3-4 times a day it's been under control. It could be just the exercise. I owe a lot to my dog.

dyna mo

oh, i misunderstood your question. I think what you are referring to is what's called insulin sensitivity. You may have had a high insulin insensitivity which led to those carbs having a greater impact on your glucose levels.

good to hear you got it sorted out !

TheSquealer

We are not supposed to be eating sugar. At all. Ever. Consider this... even natural sugars - like those in fruits. Think back 10,000 years.... What is the availability in nature of those sugars? A week or two per year? In a very limited form.

Now, think about this question very carefully...

"how do you fatten up a cow"?

You feed them not grass as they are designed to eat... but grains and sugar. You give them the exact sources of calories which diminish their bodies ability to properly process and burn the calories and are then stored as fat, That is the current human diet.

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Rochard

TheSquealer

Blood glucose levels don't have to be from sugar. All carbs, fats and proteins are all converted to glucose.

Chronically high blood glucose levels are what leads to "insulin resistance" and then Type 2 Diabetes (or Diabeetus. may peace be upon him). Distance runners who eat a carb heavy diet all their lives or body builders who eat more carbs than fat still end up with liver issues, diabetes and have heart attacks as a result of chronically high blood glucose levels.

There is a great deal of individuality in our ability to process carbs. A poor and decreasing ability is what is now called "metabolic syndrome"

A simple and kinda cool gauge of where you're at, is "the cracker test".

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Rochard

JFK

and look at this ........

"Possible side effects include hernias, infection, blood clots, ulcers, and even death."

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TheSquealer

I think it's clear that I am the exact opposite of a conspiracy theorist. But when you look at the extent to which food lobbyist have influenced policy right down to dietary recommendations, its completely insane. I am cool with Left/Right politicians and everyone having their opinions, but this issue makes me want to watch them all burn.

Senator McGovern and Ansel Keys and groups backed by Pepsi and Coke and sugar producers and farmers have killed 10s of millions of people with the completely retarded idea that THE very staple of our diet for a couple million years - fat, is bad.

A really great thing to read up on is Timothy Noakes and his fight with the South African government - where a diet itself was actually put on trial. They really brought to the light the extent to which special interests have influenced dietary recommendations backed by studies funded indirectly by companies like Coke.

A diet on trial. A nations recommended dietary guidelines and those of the West also put on trial. A pretty spectacular event... where they demonstrated that our dietary guidelines are completely wrong and are killing people wholesale,... which got no real media attention at all.

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Rochard

dyna mo

I owe a lot to my dog too!

Also, those foods you listed, potatoes, pasta, are starchy complex carbs. that means they are broken down into sugars in two distinct digestive processes. each step being a sugar.

that would explain your high glucose readings at that time.

bronco67

You know what else can reduce the beetus? Not being a glutonous fat fuck.

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dyna mo

it's important to be specific here, you're referring primarily to type 2 diabetes. As a type 1 I get a lot of people saying this sort of thing to me, but it doesn't apply. Besides the fact I'm not a glutonous fat guy.

Type 1 is an auto-immune disease. type 2 is a lifestyle disease.

While I can control my glucose #s with what i eat quite a bit, I'll always have to inject insulin.

HairyChick

OMG no, I wasn't 600 lbs. it’s a tv show! People over 600 lbs have gastric bypass and you see their lifestyle, loss, gain, etc.

I lost about eighty lbs with about thirty more to go.

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Anti-Semites have Small Penis Syndrome. The only known treatment is electroshock therapy combined with cerebellum removal. Fortunately, it’s a tiny procedure.
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HairyChick

Yep. Whole wheat pasta is better and tastes really good. White bread is poison as are most white foods. Rice, white flour, sugar, white potatoes... all carbs turning to sugar.

If you eat white potatoes with fat (butter, sour cream) it counteracts the carb/sugar effect and won’t raise your sugar. I forget which diet doctor taught me that.

Sweet potatoes have less starch but still raise your sugar.

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GFED

I've tried eating whole wheat bread and pasta and brown rice, etc. I can chew it but I need water to wash it down. I can deal with vegetables better.

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TheSquealer

You seem to really understand little about diet and nutrition.

You'r beloved whole grain bread, with the big "heart healthy: logo on it is no different than eating raw white table sugar. In fact, in almost every case, it will get into your blood as glucose faster than white table sugar. But don't let facts get in the way of a feel good narrative.

yep. if you double the calories of the potato by adding 100% more calories in fat, it will slow carbohydrate metabolism.

Good news, we know why you're overweight
Bad news, you rationalize eating horribly.

Pro Tip/Newsflash: Doctors don't study nutrition. And doctors have been passing out bad dietary advice (from the American Heart Assn, Diabetes Assn etc) since the 60s which have been the very cause of the obesity problem in the Western world.

Uhm.... no. They are similar to white potatoes in carbohydrates but more fiber slows their metabolism and thus, htey are lower on the glycemic index than white potatoes which is why athletes eat them.

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Rochard

dyna mo

That doc is simply very wrong.

grzepa

Nowdays everyone thinks he's so smart and educated and knows a lot about nutrition, just because he watched some youtube videos. Trends change, what's considered healthy now, may not appear so in few years.

The key is that you can eat everything, just dont eat too much , and dont overdo it with the obviously bad stuff, and everyone knows what it is.

And do the 15k steps a day and you should be fine

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TheSquealer

Proper nutrition and how your body is designed to eat by millions of years of evolution is not a "trend".

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Rochard

grzepa

Whats proper and whats not constantly changes and is a subject to trends.
What Im trying to say is that its good to have a common sense of whats good for you.
I believe theres no golden diet , and people are overly fixated about what they eat. Paleo diet, keto diet, vegan , vegetarian , fruitarian etc. etc.
Of course you'll not go far by eating highly processed junk, everyone knows that.

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